I've been using EMET on "maximum security" in my work environment to cut down on malware infections. However, some legitimate applications don't work, and you have to set it to "recommended" for those to load; you should be able to set back to "maximum" afterwards.
* Oracle Java 6 installer: at least as of r24; JDK 7 loads fine. I think it has to do with the Yahoo/Bing toolbar offer it has.
* Google Talk
Followup from Reddit discussion...
* No EAF for: Skype, Silverlight-Firefox
* No DEP for: Brain Workshop
* No ASLR for: Anki